Regulation of vascular smooth muscle cells phenotype by metformin up-regulated miR-1/ CCND1 axis via targeting AMPK/TGF-β signaling pathway.

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Title: Regulation of vascular smooth muscle cells phenotype by metformin up-regulated miR-1/ CCND1 axis via targeting AMPK/TGF-β signaling pathway.
Authors: Luo Y; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Clinical Trial Research Center, Ministry of Education, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China., Li M; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Clinical Trial Research Center, Ministry of Education, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.; Municipal Key Laboratory of Thrombosis and Vascular Biology, Luzhou, Sichuan, China., You J; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Clinical Trial Research Center, Ministry of Education, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.; Municipal Key Laboratory of Thrombosis and Vascular Biology, Luzhou, Sichuan, China., Jiang J; Department of General Surgery (Thyroid Surgery), The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, China., Zeng M; Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China., Luo M; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Clinical Trial Research Center, Ministry of Education, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China. luomao20050908@163.com.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. luomao20050908@163.com.; Municipal Key Laboratory of Thrombosis and Vascular Biology, Luzhou, Sichuan, China. luomao20050908@163.com.
Source: Molecular biology reports [Mol Biol Rep] 2025 Apr 29; Vol. 52 (1), pp. 437. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-4978
DOI:10.1007/s11033-025-10532-0