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GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.

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Title: GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.
Authors: Dumont V; Translational Science, Galapagos SASU, Romainville, France., Meurisse S; In Vivo Pharmacology, Galapagos SASU, Romainville, France., Verdonck K; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium., Salgues V; Translational Science, Galapagos SASU, Romainville, France., Robert T; Histology, Galapagos SASU, Romainville, France., Anquetil F; Histology, Galapagos SASU, Romainville, France., Delachaume C; In Vivo Pharmacology, Galapagos SASU, Romainville, France., Blanqué R; Translational Science, Galapagos SASU, Romainville, France., Liekens D; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium., Huang Y; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Hu J; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Nephrology and Hypertension, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Harris PC; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Nephrology and Hypertension, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Nakhlé J; Translational Research, Galapagos SASU, Romainville, France., Conrath K; Target and Pathway Modulation, Galapagos NV, Mechelen, Belgium., Vandeghinste N; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium, nick.vandeghinste@glpg.com., Christophe T; Therapeutic Area, Galapagos NV, Mechelen, Belgium, thierry.christophe@calliditas.com., Comas D; In Vivo Pharmacology, Galapagos SASU, Romainville, France, dcomas@novalix.com.
Source: American journal of nephrology [Am J Nephrol] 2025; Vol. 56 (6), pp. 802-811. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 8109361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9670 (Electronic) Linking ISSN: 02508095 NLM ISO Abbreviation: Am J Nephrol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.
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  Data: <searchLink fieldCode="AU" term="%22Dumont+V%22">Dumont V</searchLink>; Translational Science, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Meurisse+S%22">Meurisse S</searchLink>; In Vivo Pharmacology, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Verdonck+K%22">Verdonck K</searchLink>; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium.<br /><searchLink fieldCode="AU" term="%22Salgues+V%22">Salgues V</searchLink>; Translational Science, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Robert+T%22">Robert T</searchLink>; Histology, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Anquetil+F%22">Anquetil F</searchLink>; Histology, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Delachaume+C%22">Delachaume C</searchLink>; In Vivo Pharmacology, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Blanqué+R%22">Blanqué R</searchLink>; Translational Science, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Liekens+D%22">Liekens D</searchLink>; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Nephrology and Hypertension, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Harris+PC%22">Harris PC</searchLink>; Mayo Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Nephrology and Hypertension, School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Nakhlé+J%22">Nakhlé J</searchLink>; Translational Research, Galapagos SASU, Romainville, France.<br /><searchLink fieldCode="AU" term="%22Conrath+K%22">Conrath K</searchLink>; Target and Pathway Modulation, Galapagos NV, Mechelen, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandeghinste+N%22">Vandeghinste N</searchLink>; Kidney Therapeutic Area Group, Galapagos NV, Mechelen, Belgium, nick.vandeghinste@glpg.com.<br /><searchLink fieldCode="AU" term="%22Christophe+T%22">Christophe T</searchLink>; Therapeutic Area, Galapagos NV, Mechelen, Belgium, thierry.christophe@calliditas.com.<br /><searchLink fieldCode="AU" term="%22Comas+D%22">Comas D</searchLink>; In Vivo Pharmacology, Galapagos SASU, Romainville, France, dcomas@novalix.com.
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