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Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.

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Title: Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Authors: Liang X; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. xiuming.liang@ki.se.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden. xiuming.liang@ki.se.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden. xiuming.liang@ki.se.; Cancer Research Laboratory, Shandong University-Karolinska Institutet collaborative Laboratory, School of Basic Medical Science, Shandong University, Jinan, Shandong, PR China. xiuming.liang@ki.se., Gupta D; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK., Xie J; VIB Center for Inflammation Research, VIB, 9052, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052, Ghent, Belgium., Van Wonterghem E; VIB Center for Inflammation Research, VIB, 9052, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052, Ghent, Belgium., Van Hoecke L; VIB Center for Inflammation Research, VIB, 9052, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052, Ghent, Belgium., Hean J; Evox Therapeutics Limited, Oxford, United Kingdom., Niu Z; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Ghaeidamini M; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, 41296, Göteborg, Sweden., Wiklander OPB; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden., Zheng W; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Wiklander RJ; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., He R; Experimental Cancer Medicine, Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet., Stockholm, Sweden., Mamand DR; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Breast Center, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden., Bost J; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Zhou G; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, 419 Fang-Xie Road, Shanghai, 200011, P.R. China., Zhou H; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Roudi S; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Estupiñán HY; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden.; Departamento de Ciencias Basicas, Universidad Industrial de Santander, Bucaramanga, Colombia., Rädler J; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Zickler AM; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Görgens A; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden.; Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hou VWQ; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., Slovak R; Evox Therapeutics Limited, Oxford, United Kingdom., Hagey DW; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden., de Jong OG; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, 3584 CG, The Netherlands., Uy AG; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Zong Y; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, 250021, PR China., Mäger I; Institute of Technology, University of Tartu, 50 411, Tartu, Estonia., Perez CM; Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK., Roberts TC; Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.; MDUK Oxford Neuromuscular Centre, Oxford, OX3 7TY, UK., Carter D; Evox Therapeutics Limited, Oxford, United Kingdom., Vader P; CDL Research, University Medical Center Utrecht, Utrecht, Netherlands.; Department of Experimental Cardiology, University Medical Center Utrecht, Utrecht, Netherlands., Esbjörner EK; Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, 41296, Göteborg, Sweden., de Fougerolles A; Evox Therapeutics Limited, Oxford, United Kingdom., Wood MJA; Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.; MDUK Oxford Neuromuscular Centre, Oxford, OX3 7TY, UK., Vandenbroucke RE; VIB Center for Inflammation Research, VIB, 9052, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, 9052, Ghent, Belgium., Nordin JZ; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. joel.nordin@ki.se.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden. joel.nordin@ki.se.; Department of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital, Stockholm, Sweden. joel.nordin@ki.se., El Andaloussi S; Division for Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. samir.el-andaloussi@ki.se.; Karolinska ATMP Center, ANA Futura, Karolinska Institutet, Stockholm, Sweden. samir.el-andaloussi@ki.se.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden. samir.el-andaloussi@ki.se.
Source: Nature communications [Nat Commun] 2025 Apr 29; Vol. 16 (1), pp. 4028. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59377-y