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Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis.

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Title: Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis.
Authors: Chan BK; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA., Stanley GL; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Kortright KE; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA., Vill AC; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA., Modak M; Department of Medicine, Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Ott IM; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA., Sun Y; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Würstle S; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Internal Medicine, Infectious Diseases, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany., Grun CN; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Kazmierczak BI; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Rajagopalan G; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Harris ZM; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Britto CJ; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Stewart J; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Talwalkar JS; Department of Internal Medicine, Section General Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA., Appell CR; Department of Kinesiology & Sports Management, Texas Tech University, Lubbock, TX, USA., Chaudary N; Department of Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA., Jagpal SK; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Jain R; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kanu A; Department of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA., Quon BS; Faculty of Medicine, Centre for Heart Lung Innovation, The University of British Columbia, Vancouver, British Columbia, Canada., Reynolds JM; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA., Teneback CC; Department of Medicine, Division of Pulmonary Disease and Critical Care Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA., Mai QA; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA., Shabanova V; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA., Turner PE; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Program in Microbiology, Yale School of Medicine, New Haven, CT, USA., Koff JL; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA. jon.koff@yale.edu.; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA. jon.koff@yale.edu.
Source: Nature medicine [Nat Med] 2025 May; Vol. 31 (5), pp. 1494-1501. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chan+BK%22">Chan BK</searchLink>; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Stanley+GL%22">Stanley GL</searchLink>; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.; Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kortright+KE%22">Kortright KE</searchLink>; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Vill+AC%22">Vill AC</searchLink>; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.; Center for Phage Biology and Therapy, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Modak+M%22">Modak M</searchLink>; 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