GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice.

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Title: GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice.
Authors: Liu CM; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA.; Amgen R&D Postdoctoral Fellows Program, Amgen Inc., Thousand Oaks, CA, USA., Killion EA; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Hammoud R; The Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Lu SC; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Komorowski R; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Liu T; Center for Research Acceleration by Digital Innovation, Amgen Research, Thousand Oaks, CA, USA., Kanke M; Department of Research Technologies, Amgen Research, South San Francisco, CA, USA., Thomas VA; Department of Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Cook K; Department of Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Sivits GN Jr; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Ben AB; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Atangan LI; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Hussien R; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Tang A; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Shkumatov A; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Li CM; Department of Research Technologies, Amgen Research, South San Francisco, CA, USA., Drucker DJ; The Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Véniant MM; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA. mveniant@amgen.com.
Source: Nature metabolism [Nat Metab] 2025 Jun; Vol. 7 (6), pp. 1266-1281. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2522-5812
DOI:10.1038/s42255-025-01295-w