GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice.
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| Title: | GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice. |
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| Authors: | Liu CM; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA.; Amgen R&D Postdoctoral Fellows Program, Amgen Inc., Thousand Oaks, CA, USA., Killion EA; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Hammoud R; The Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Lu SC; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Komorowski R; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Liu T; Center for Research Acceleration by Digital Innovation, Amgen Research, Thousand Oaks, CA, USA., Kanke M; Department of Research Technologies, Amgen Research, South San Francisco, CA, USA., Thomas VA; Department of Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Cook K; Department of Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, USA., Sivits GN Jr; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Ben AB; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Atangan LI; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Hussien R; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Tang A; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Shkumatov A; Department of Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, CA, USA., Li CM; Department of Research Technologies, Amgen Research, South San Francisco, CA, USA., Drucker DJ; The Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Véniant MM; Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA. mveniant@amgen.com. |
| Source: | Nature metabolism [Nat Metab] 2025 Jun; Vol. 7 (6), pp. 1266-1281. Date of Electronic Publication: 2025 Apr 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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