Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.
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| Title: | Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation. |
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| Authors: | Lawrence EM; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Cooray A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Kueh AJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Pal M; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia., Tai L; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia., Garnham AL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Li-Wai-Suen CSN; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Vanyai H; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Gouil Q; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Lancaster J; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Callegari S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Whelan L; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lieschke E; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Thomas A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Strasser A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Liao Y; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Shi W; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Wei AH; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Herold MJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia. Marco.Herold@onjcri.org.au.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia. Marco.Herold@onjcri.org.au. |
| Source: | EMBO reports [EMBO Rep] 2025 Jun; Vol. 26 (11), pp. 2855-2882. Date of Electronic Publication: 2025 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-025-00450-4 |
