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Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.

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Title: Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.
Authors: Lawrence EM; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Cooray A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Kueh AJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Pal M; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia., Tai L; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia., Garnham AL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Li-Wai-Suen CSN; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Vanyai H; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Gouil Q; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Lancaster J; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Callegari S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Whelan L; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lieschke E; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Oncogene Biology Laboratory, Francis Crick Institute, London, UK., Thomas A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Strasser A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Liao Y; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Shi W; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia., Wei AH; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Herold MJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia. Marco.Herold@onjcri.org.au.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia. Marco.Herold@onjcri.org.au.
Source: EMBO reports [EMBO Rep] 2025 Jun; Vol. 26 (11), pp. 2855-2882. Date of Electronic Publication: 2025 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lawrence+EM%22">Lawrence EM</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cooray+A%22">Cooray A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kueh+AJ%22">Kueh AJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Pal+M%22">Pal M</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Tai+L%22">Tai L</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.<br /><searchLink fieldCode="AU" term="%22Garnham+AL%22">Garnham AL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Li-Wai-Suen+CSN%22">Li-Wai-Suen CSN</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Vanyai+H%22">Vanyai H</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gouil+Q%22">Gouil Q</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lancaster+J%22">Lancaster J</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Callegari+S%22">Callegari S</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Whelan+L%22">Whelan L</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lieschke+E%22">Lieschke E</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Oncogene Biology Laboratory, Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+A%22">Thomas A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Strasser+A%22">Strasser A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Shi+W%22">Shi W</searchLink>; Olivia Newton John Cancer Research Institute, Heidelberg, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+AH%22">Wei AH</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Herold+MJ%22">Herold MJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Marco.Herold@onjcri.org.au.; Olivia Newton John Cancer Research Institute, Heidelberg, Australia. Marco.Herold@onjcri.org.au.; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia. Marco.Herold@onjcri.org.au.
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