Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy.
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| Title: | Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy. |
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| Authors: | Liu C; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, Neurosurgical Institute of Fudan University, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Liu Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, Neurosurgical Institute of Fudan University, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Lin H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, Neurosurgical Institute of Fudan University, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Zhang C; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Zhang B; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Song H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Fan X; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China., Lyu Y; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China., Yang H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, Neurosurgical Institute of Fudan University, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China., Mao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.; National Center for Neurological Disorders, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, Neurosurgical Institute of Fudan University, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Apr 16; Vol. 16, pp. 1587009. Date of Electronic Publication: 2025 Apr 16 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1587009 |
