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Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy.

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Title: Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy.
Authors: Golnari P; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Prantzalos K; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Hood V; Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA., Meskis MA; Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA., Isom LL; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-5632, USA., Wilcox K; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA., Parent JM; Department of Neurology and Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Lal D; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Neurogenetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and M.I.T., Cambridge, MA 02142, USA., Lhatoo SD; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Goodkin HP; Department of Neurology and Pediatrics, University of Virginia, Charlottesville VA 22903, USA., Wirrell EC; Divisions of Child & Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA., Knupp KG; Department of Pediatrics and Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Patel M; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA., Loeb JA; Department of Neurology and Rehabilitation, University of Illinois Chicago, Chicago, IL 60612, USA., Sullivan JE; Departments of Neurology and Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA 94158, USA., Harte-Hargrove L; CURE Epilepsy, Chicago, IL 60611, USA., Fureman BE; Epilepsy Foundation, 3540 Crain Highway, Suite 675, Bowie, MD 20716, USA., Buchhalter J; Department of Pediatrics, University of Calgary School of Medicine, Calgary AB T2N 4N1, Canada., Sahoo SS; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Source: International journal of medical informatics [Int J Med Inform] 2025 Sep; Vol. 201, pp. 105942. Date of Electronic Publication: 2025 Apr 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 9711057 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8243 (Electronic) Linking ISSN: 13865056 NLM ISO Abbreviation: Int J Med Inform Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy.
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  Data: <searchLink fieldCode="AU" term="%22Golnari+P%22">Golnari P</searchLink>; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Prantzalos+K%22">Prantzalos K</searchLink>; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Hood+V%22">Hood V</searchLink>; Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA.<br /><searchLink fieldCode="AU" term="%22Meskis+MA%22">Meskis MA</searchLink>; Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA.<br /><searchLink fieldCode="AU" term="%22Isom+LL%22">Isom LL</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-5632, USA.<br /><searchLink fieldCode="AU" term="%22Wilcox+K%22">Wilcox K</searchLink>; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Parent+JM%22">Parent JM</searchLink>; Department of Neurology and Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Lal+D%22">Lal D</searchLink>; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Neurogenetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and M.I.T., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Lhatoo+SD%22">Lhatoo SD</searchLink>; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Goodkin+HP%22">Goodkin HP</searchLink>; Department of Neurology and Pediatrics, University of Virginia, Charlottesville VA 22903, USA.<br /><searchLink fieldCode="AU" term="%22Wirrell+EC%22">Wirrell EC</searchLink>; Divisions of Child & Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Knupp+KG%22">Knupp KG</searchLink>; Department of Pediatrics and Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Patel+M%22">Patel M</searchLink>; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Loeb+JA%22">Loeb JA</searchLink>; Department of Neurology and Rehabilitation, University of Illinois Chicago, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+JE%22">Sullivan JE</searchLink>; Departments of Neurology and Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Harte-Hargrove+L%22">Harte-Hargrove L</searchLink>; CURE Epilepsy, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Fureman+BE%22">Fureman BE</searchLink>; Epilepsy Foundation, 3540 Crain Highway, Suite 675, Bowie, MD 20716, USA.<br /><searchLink fieldCode="AU" term="%22Buchhalter+J%22">Buchhalter J</searchLink>; Department of Pediatrics, University of Calgary School of Medicine, Calgary AB T2N 4N1, Canada.<br /><searchLink fieldCode="AU" term="%22Sahoo+SS%22">Sahoo SS</searchLink>; Department of Population and Quantitative Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
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  Data: <searchLink fieldCode="JN" term="%229711057%22">International journal of medical informatics</searchLink> [Int J Med Inform] 2025 Sep; Vol. 201, pp. 105942. <i>Date of Electronic Publication: </i>2025 Apr 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland+Ltd%22">Elsevier Science Ireland Ltd </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>9711057 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-8243 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213865056%22">13865056 </searchLink><i>NLM ISO Abbreviation: </i>Int J Med Inform <i>Subsets: </i>MEDLINE
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