High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.

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Title: High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.
Authors: Guan H; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chen J; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jia.chen@mssm.edu., Kaur K; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amreen B; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lesseur C; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dolios G; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Andra SS; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Narasimhan S; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pulivarthi D; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Midya V; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., De Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bergink V; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rommel AS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Petrick LM; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Bert Strassburger Metabolic Center, Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: lauren.petrick@mssm.edu.
Source: The Science of the total environment [Sci Total Environ] 2025 Jun 10; Vol. 980, pp. 179520. Date of Electronic Publication: 2025 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-1026
DOI:10.1016/j.scitotenv.2025.179520