High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.

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Title: High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.
Authors: Guan H; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chen J; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jia.chen@mssm.edu., Kaur K; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amreen B; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lesseur C; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dolios G; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Andra SS; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Narasimhan S; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pulivarthi D; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Midya V; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., De Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bergink V; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rommel AS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Petrick LM; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Bert Strassburger Metabolic Center, Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: lauren.petrick@mssm.edu.
Source: The Science of the total environment [Sci Total Environ] 2025 Jun 10; Vol. 980, pp. 179520. Date of Electronic Publication: 2025 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy.
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  Data: <searchLink fieldCode="AU" term="%22Guan+H%22">Guan H</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jia.chen@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Kaur+K%22">Kaur K</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Amreen+B%22">Amreen B</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Lesseur+C%22">Lesseur C</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Dolios+G%22">Dolios G</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Andra+SS%22">Andra SS</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Narasimhan+S%22">Narasimhan S</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Pulivarthi+D%22">Pulivarthi D</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Midya+V%22">Midya V</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22De+Witte+LD%22">De Witte LD</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Bergink+V%22">Bergink V</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Rommel+AS%22">Rommel AS</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Petrick+LM%22">Petrick LM</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Bert Strassburger Metabolic Center, Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: lauren.petrick@mssm.edu.
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