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Impact of L-arginine and liposomal vitamin C supplementation on quality of life and daily life activities in patients with COPD: a randomized, multicenter, single blind, placebo-controlled trial (ILDA study).

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Title: Impact of L-arginine and liposomal vitamin C supplementation on quality of life and daily life activities in patients with COPD: a randomized, multicenter, single blind, placebo-controlled trial (ILDA study).
Authors: Radovanovic D; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy; Coordinated Research Center on Respiratory Failure, University of Milan, Milano, Italy., Signorello JC; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy., Fuccia G; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy., Lazzaroni G; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy., Danzo F; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy., Guandalini GM; School of Medicine and Surgery, Università degli Studi di Milano, Milano, Italy., Massaro F; Cardiac and Pneumological Rehabilitation Medicine, Codogno Hospital, Lodi, Italy., Tursi F; Cardiac and Pneumological Rehabilitation Medicine, Codogno Hospital, Lodi, Italy., Santus P; Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milano, Italy; Coordinated Research Center on Respiratory Failure, University of Milan, Milano, Italy. Electronic address: pierachille.santus@unimi.it.
Source: European journal of internal medicine [Eur J Intern Med] 2025 Jun; Vol. 136, pp. 107-116. Date of Electronic Publication: 2025 May 01.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0828
DOI:10.1016/j.ejim.2025.04.039