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An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling.

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Title: An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling.
Authors: Zheng A; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China., Han T; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China., Bu F; Department of Pharmacy, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China., He Q; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China., Shang J; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China., Ho PCL; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia., Xiang X; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China. xiangxq@fudan.edu.cn.; Quzhou Fudan Institute, Quzhou, 324002, Zhejiang Province, China. xiangxq@fudan.edu.cn.; National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai, China. xiangxq@fudan.edu.cn., Zhou X; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. doctzhouxingtao@163.com.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China. doctzhouxingtao@163.com.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China. doctzhouxingtao@163.com.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China. doctzhouxingtao@163.com., Huang T; Department of Pharmacy, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. taominhuang@fudan.edu.cn.
Source: The AAPS journal [AAPS J] 2025 May 02; Vol. 27 (4), pp. 89. Date of Electronic Publication: 2025 May 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+A%22">Zheng A</searchLink>; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Han+T%22">Han T</searchLink>; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bu+F%22">Bu F</searchLink>; Department of Pharmacy, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Shang+J%22">Shang J</searchLink>; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ho+PCL%22">Ho PCL</searchLink>; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.<br /><searchLink fieldCode="AU" term="%22Xiang+X%22">Xiang X</searchLink>; Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, 201203, China. xiangxq@fudan.edu.cn.; Quzhou Fudan Institute, Quzhou, 324002, Zhejiang Province, China. xiangxq@fudan.edu.cn.; National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai, China. xiangxq@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. doctzhouxingtao@163.com.; Key Laboratory of Myopia, NHC Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, 83 Fenyang Road, Shanghai, 200031, China. doctzhouxingtao@163.com.; Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200081, China. doctzhouxingtao@163.com.; Shanghai Engineering Research Center of Laser and Autostereoscopic 3d for Vision Care (20dz2255000), Shanghai, China. doctzhouxingtao@163.com.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Department of Pharmacy, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. taominhuang@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2025 May 02; Vol. 27 (4), pp. 89. <i>Date of Electronic Publication: </i>2025 May 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE
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        Value: 10.1208/s12248-025-01052-7
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        Text: English
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            NameFull: Zheng A
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            NameFull: Han T
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            – D: 02
              M: 05
              Text: 2025 May 02
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              Y: 2025
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