Synergistic Activity of Combined FLT3-ITD and MDM2 Inhibition with Quizartinib and Milademetan in FLT3-ITD Mutant/TP53 Wild-type Acute Myeloid Leukemias.
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| Title: | Synergistic Activity of Combined FLT3-ITD and MDM2 Inhibition with Quizartinib and Milademetan in FLT3-ITD Mutant/TP53 Wild-type Acute Myeloid Leukemias. |
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| Authors: | Zhang W; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Li L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Muftuoglu M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Basyal M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Togashi N; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Iwanaga K; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Tanzawa F; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Numata M; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Bixby DL; Hematologic Oncology, University of Michigan Medical School, Ann Arbor, Michigan., Erba HP; Hematologic Malignancies and Cellular Therapy, Duke University, Durham, North Carolina., Podoltsev N; Hematology Section, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut., Schiller GJ; Hematologic Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California., Kumar P; Daiichi Sankyo, Inc., Basking Ridge, New Jersey., Lesegretain A; Daiichi Sankyo, Inc., Basking Ridge, New Jersey., Isoyama T; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Seki T; Daiichi Sankyo, Inc., Basking Ridge, New Jersey., Daver N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. |
| Source: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Jul 15; Vol. 31 (14), pp. 3033-3047. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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