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HDX-MS reveals pH and temperature-responsive regions on AAV capsids and the structural basis for DNA release.

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Title: HDX-MS reveals pH and temperature-responsive regions on AAV capsids and the structural basis for DNA release.
Authors: Ye X; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA. xiang.ye@regeneron.com., Hu M; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA., Hu Y; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA. yunli.hu@regeneron.com., Qiu H; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA., Li N; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA.
Source: Gene therapy [Gene Ther] 2025 Dec; Vol. 32 (6), pp. 621-631. Date of Electronic Publication: 2025 May 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA. xiang.ye@regeneron.com.<br /><searchLink fieldCode="AU" term="%22Hu+M%22">Hu M</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA. yunli.hu@regeneron.com.<br /><searchLink fieldCode="AU" term="%22Qiu+H%22">Qiu H</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA.<br /><searchLink fieldCode="AU" term="%22Li+N%22">Li N</searchLink>; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591-6707, USA.
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  Data: <searchLink fieldCode="JN" term="%229421525%22">Gene therapy</searchLink> [Gene Ther] 2025 Dec; Vol. 32 (6), pp. 621-631. <i>Date of Electronic Publication: </i>2025 May 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421525 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5462 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209697128%22">09697128 </searchLink><i>NLM ISO Abbreviation: </i>Gene Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41434-025-00539-4
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      – Code: eng
        Text: English
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      – TitleFull: HDX-MS reveals pH and temperature-responsive regions on AAV capsids and the structural basis for DNA release.
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              Text: 2025 Dec
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