Fast product release requires active-site water dynamics in carbonic anhydrase.

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Title: Fast product release requires active-site water dynamics in carbonic anhydrase.
Authors: Kim JK; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; Frontier of Extreme Physics, Korea Research Institute of Standards and Science, Daejeon, 34113, Republic of Korea., Lim SW; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Jeong H; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Lee C; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Kim S; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Son DW; Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju, 52828, Republic of Korea.; Anti-Aging Bio Cell Factory Regional Leading Research Center (ABC-RLRC), Gyeongsang National University, Jinju, 52828, Republic of Korea., Kumar R; Department of Chemistry, Pusan National University, Busan, 46241, Republic of Korea.; Chemistry Institute for Functional Materials, Pusan National University, Busan, 46241, Republic of Korea., Andring JT; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA., Lomelino C; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA., Wierman JL; Cornell High Energy Synchrotron Source, Cornell University, Ithaca, New York, 14853, USA., Cohen AE; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, 94025, USA., Shin TJ; Graduate School of Semiconductor Materials and Devices Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Ghim CM; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., McKenna R; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA., Jo BH; Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju, 52828, Republic of Korea.; Anti-Aging Bio Cell Factory Regional Leading Research Center (ABC-RLRC), Gyeongsang National University, Jinju, 52828, Republic of Korea.; Research Institute of Life Science, Gyeongsang National University, Jinju, 52828, Republic of Korea., Min D; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Choi JM; Department of Chemistry, Pusan National University, Busan, 46241, Republic of Korea.; Chemistry Institute for Functional Materials, Pusan National University, Busan, 46241, Republic of Korea., Kim CU; Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. cukim@unist.ac.kr.
Source: Nature communications [Nat Commun] 2025 May 12; Vol. 16 (1), pp. 4404. Date of Electronic Publication: 2025 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59645-x