Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations.

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Title: Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations.
Authors: Fisher DG; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Cruz T; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Hoch MR; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Sharifi KA; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.; Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA., Shah IM; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Gorick CM; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Breza VR; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Debski AC; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Samuels JD; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA., Sheehan JP; Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA., Schlesinger D; Department of Radiation Oncology, University of Virginia Health System, Charlottesville, VA, USA., Moore D; Focused Ultrasound Foundation, Charlottesville, VA, USA., Mandell JW; Department of Pathology, University of Virginia, Charlottesville, VA, USA., Lukens JR; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA., Miller GW; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA., Tvrdik P; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA. pt8bm.uva@gmail.com.; Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA. pt8bm.uva@gmail.com., Price RJ; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. rprice@virginia.edu.; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA. rprice@virginia.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Sep; Vol. 9 (9), pp. 1531-1546. Date of Electronic Publication: 2025 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2157-846X
DOI:10.1038/s41551-025-01390-z