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Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold.

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Title: Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold.
Authors: Doruk YU; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States., Diolaiti ME; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States., Ashworth A; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States.; Department of Medicine, University of California, San Francisco, California 94158, United States., Talele TT; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 Apr 03; Vol. 16 (5), pp. 776-783. Date of Electronic Publication: 2025 Apr 03 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Doruk+YU%22">Doruk YU</searchLink>; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States.<br /><searchLink fieldCode="AU" term="%22Diolaiti+ME%22">Diolaiti ME</searchLink>; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States.<br /><searchLink fieldCode="AU" term="%22Ashworth+A%22">Ashworth A</searchLink>; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, United States.; Department of Medicine, University of California, San Francisco, California 94158, United States.<br /><searchLink fieldCode="AU" term="%22Talele+TT%22">Talele TT</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2025 Apr 03; Vol. 16 (5), pp. 776-783. <i>Date of Electronic Publication: </i>2025 Apr 03 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1021/acsmedchemlett.4c00603
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      – Code: eng
        Text: English
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      – TitleFull: Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold.
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            NameFull: Doruk YU
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            NameFull: Diolaiti ME
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              Text: 2025 Apr 03
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