A human-specific enhancer fine-tunes radial glia potency and corticogenesis.

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Title: A human-specific enhancer fine-tunes radial glia potency and corticogenesis.
Authors: Liu J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Mosti F; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA., Zhao HT; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA., Lollis D; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Sotelo-Fonseca JE; Department of Biology, Duke University, Durham, NC, USA., Escobar-Tomlienovich CF; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Musso CM; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Mao Y; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Massri AJ; Department of Biology, Duke University, Durham, NC, USA., Doll HM; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Moss ND; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Sousa AMM; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Wray GA; Department of Biology, Duke University, Durham, NC, USA., Schmidt ERE; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA., Silver DL; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. debra.silver@duke.edu.; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA. debra.silver@duke.edu.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. debra.silver@duke.edu.; Duke Institute for Brain Sciences and Duke Regeneration Center, Duke University Medical Center, Durham, NC, USA. debra.silver@duke.edu.
Source: Nature [Nature] 2025 Jul; Vol. 643 (8074), pp. 1321-1332. Date of Electronic Publication: 2025 May 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-09002-1