Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2-dependent statine pathway.
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| Title: | Tandem ketone reduction in pepstatin biosynthesis reveals an F |
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| Authors: | Mo J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Helmholtz International Lab for Anti-Infectives, Helmholtz Center for Infection Research, Braunschweig, Germany., Sikandar A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany., Zhao H; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Helmholtz International Lab for Anti-Infectives, Helmholtz Center for Infection Research, Braunschweig, Germany., Bashiri G; Laboratory of Microbial Biochemistry and Biotechnology, School of Biological Sciences, University of Auckland, Private Bag, Auckland, New Zealand., Huo L; State Key Laboratory of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University, Qingdao, China., Empting M; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; German Centre for Infection Research (DZIF), Braunschweig, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Müller R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Helmholtz International Lab for Anti-Infectives, Helmholtz Center for Infection Research, Braunschweig, Germany.; German Centre for Infection Research (DZIF), Braunschweig, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Fu C; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany. chengzhang.fu@helmholtz-hips.de.; Helmholtz International Lab for Anti-Infectives, Helmholtz Center for Infection Research, Braunschweig, Germany. chengzhang.fu@helmholtz-hips.de. |
| Source: | Nature communications [Nat Commun] 2025 May 15; Vol. 16 (1), pp. 4531. Date of Electronic Publication: 2025 May 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59785-0 |
