siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.

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Title: siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.
Authors: Colazo JM; Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA., Keech MC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Shah V; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lo JH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cassidy NT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., McCune JT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., DeJulius CR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cho H; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gibson-Corley KN; Department of Pathology, Microbiology, and Immunology, Division of Comparative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hasty KA; Department of Orthopaedic Surgery and Biomedical Engineering, UTHSC, Memphis VA Medical Center, Memphis, TN, USA., Crofford LJ; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Cook RS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. craig.duvall@vanderbilt.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Aug; Vol. 9 (8), pp. 1366-1383. Date of Electronic Publication: 2025 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01376-x