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Exploring the Anticancer Potential of Lamivudine-Loaded Polymeric Nanoparticles: In Vitro Cytotoxicity, Tissue Deposition, Biochemical Impact In Vivo, and Molecular Simulations Analysis.

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Title: Exploring the Anticancer Potential of Lamivudine-Loaded Polymeric Nanoparticles: In Vitro Cytotoxicity, Tissue Deposition, Biochemical Impact In Vivo, and Molecular Simulations Analysis.
Authors: Gomes-da-Silva NC; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil., de Faria Almeida A; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil., Severino P; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil., Al-Qahtani M; Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11564, Saudi Arabia., Rebelo Alencar LM; Biophysics and Nanosystems Laboratory, Federal University of Maranhão, Department of Physics, São Luis 65065690, MA Brazil., Fechine PBA; Grupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará-UFC, Campus do Pici, CP 12100, Fortaleza, 60451-970, CE Brazil., Ricci-Junior E; Federal University of Rio de Janeiro, School of Pharmacy, Rio de Janeiro 21941900, RJ Brazil., Osmari Vendrame LF; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil., da Rocha JAP; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil.; Laboratory of Modeling and Computational Chemistry, Federal Institute of Education, Science and Technology of Pará (IFPA), Campus Bragança 68600-000, PA Brazil., Fagan SB; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil.; Rio de Janeiro State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro 23070200, RJ Brazil.
Source: ACS applied bio materials [ACS Appl Bio Mater] 2025 Jun 16; Vol. 8 (6), pp. 4815-4828. Date of Electronic Publication: 2025 May 19.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE
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  Data: Exploring the Anticancer Potential of Lamivudine-Loaded Polymeric Nanoparticles: In Vitro Cytotoxicity, Tissue Deposition, Biochemical Impact In Vivo, and Molecular Simulations Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Gomes-da-Silva+NC%22">Gomes-da-Silva NC</searchLink>; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil.<br /><searchLink fieldCode="AU" term="%22de+Faria+Almeida+A%22">de Faria Almeida A</searchLink>; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Severino+P%22">Severino P</searchLink>; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Al-Qahtani+M%22">Al-Qahtani M</searchLink>; Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11564, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Rebelo+Alencar+LM%22">Rebelo Alencar LM</searchLink>; Biophysics and Nanosystems Laboratory, Federal University of Maranhão, Department of Physics, São Luis 65065690, MA Brazil.<br /><searchLink fieldCode="AU" term="%22Fechine+PBA%22">Fechine PBA</searchLink>; Grupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará-UFC, Campus do Pici, CP 12100, Fortaleza, 60451-970, CE Brazil.<br /><searchLink fieldCode="AU" term="%22Ricci-Junior+E%22">Ricci-Junior E</searchLink>; Federal University of Rio de Janeiro, School of Pharmacy, Rio de Janeiro 21941900, RJ Brazil.<br /><searchLink fieldCode="AU" term="%22Osmari+Vendrame+LF%22">Osmari Vendrame LF</searchLink>; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil.<br /><searchLink fieldCode="AU" term="%22da+Rocha+JAP%22">da Rocha JAP</searchLink>; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil.; Laboratory of Modeling and Computational Chemistry, Federal Institute of Education, Science and Technology of Pará (IFPA), Campus Bragança 68600-000, PA Brazil.<br /><searchLink fieldCode="AU" term="%22Fagan+SB%22">Fagan SB</searchLink>; Franciscan University, Rua dos Andradas 1614, Santa Maria 97010-100, RS Brazil.<br /><searchLink fieldCode="AU" term="%22Santos-Oliveira+R%22">Santos-Oliveira R</searchLink>; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro 21941906, RJ Brazil.; Rio de Janeiro State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro 23070200, RJ Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101729147%22">ACS applied bio materials</searchLink> [ACS Appl Bio Mater] 2025 Jun 16; Vol. 8 (6), pp. 4815-4828. <i>Date of Electronic Publication: </i>2025 May 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ACS+Publications%22">ACS Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101729147 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2576-6422 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225766422%22">25766422 </searchLink><i>NLM ISO Abbreviation: </i>ACS Appl Bio Mater <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun 16
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