Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
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| Title: | Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12. |
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| Authors: | Troester S; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Eder T; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Wukowits N; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Piontek M; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Fernández-Pernas P; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Schmoellerl J; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria., Haladik B; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Manhart G; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Allram M; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Maurer-Granofszky M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Scheidegger N; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Nebral K; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Labdia Labordiagnostik, Vienna, Austria., Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Bornhauser B; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseologay, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Dworzak MN; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria., Zuber J; Research Institute of Molecular Pathology (IMP), Vienna, Austria.; Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria., Boztug K; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Grebien F; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria. florian.grebien@vetmeduni.ac.at.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. florian.grebien@vetmeduni.ac.at.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. florian.grebien@vetmeduni.ac.at. |
| Source: | Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4656. Date of Electronic Publication: 2025 May 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59930-9 |
