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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

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Title: Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
Authors: Troester S; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Eder T; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Wukowits N; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Piontek M; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Fernández-Pernas P; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Schmoellerl J; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria., Haladik B; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Manhart G; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Allram M; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria., Maurer-Granofszky M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Scheidegger N; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Nebral K; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Labdia Labordiagnostik, Vienna, Austria., Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Bornhauser B; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseologay, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Dworzak MN; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria., Zuber J; Research Institute of Molecular Pathology (IMP), Vienna, Austria.; Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria., Boztug K; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Grebien F; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria. florian.grebien@vetmeduni.ac.at.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. florian.grebien@vetmeduni.ac.at.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. florian.grebien@vetmeduni.ac.at.
Source: Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4656. Date of Electronic Publication: 2025 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
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  Data: <searchLink fieldCode="AU" term="%22Troester+S%22">Troester S</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Eder+T%22">Eder T</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wukowits+N%22">Wukowits N</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Piontek+M%22">Piontek M</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fernández-Pernas+P%22">Fernández-Pernas P</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schmoellerl+J%22">Schmoellerl J</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.; Research Institute of Molecular Pathology (IMP), Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Haladik+B%22">Haladik B</searchLink>; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Manhart+G%22">Manhart G</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Allram+M%22">Allram M</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Maurer-Granofszky+M%22">Maurer-Granofszky M</searchLink>; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Scheidegger+N%22">Scheidegger N</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nebral+K%22">Nebral K</searchLink>; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Labdia Labordiagnostik, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Superti-Furga+G%22">Superti-Furga G</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Meisel+R%22">Meisel R</searchLink>; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Valent+P%22">Valent P</searchLink>; Department of Internal Medicine I, Division of Hematology and Hemostaseologay, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dworzak+MN%22">Dworzak MN</searchLink>; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Zuber+J%22">Zuber J</searchLink>; Research Institute of Molecular Pathology (IMP), Vienna, Austria.; Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Boztug+K%22">Boztug K</searchLink>; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Grebien+F%22">Grebien F</searchLink>; Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria. florian.grebien@vetmeduni.ac.at.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. florian.grebien@vetmeduni.ac.at.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. florian.grebien@vetmeduni.ac.at.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4656. <i>Date of Electronic Publication: </i>2025 May 19.
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