ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1.
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| Title: | ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1. |
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| Authors: | Rincon-Torroella J; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States., Dal Molin M; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, United States., Mog B; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Chevy Chase, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, United States., Han G; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States., Watson E; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States., Wyhs N; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, United States., Ishiyama S; Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, United States., Ahmedna T; Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, United States., Minn I; Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, United States., Azad N; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States., Bettegowda C; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States., Papadopoulos N; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States., Kinzler KW; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States., Zhou S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States., Vogelstein B; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Howard Hughes Medical Institute, Chevy Chase, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States., Gabrielson K; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, United States., Sur S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, United States.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, United States. |
| Source: | ELife [Elife] 2025 May 20; Vol. 13. Date of Electronic Publication: 2025 May 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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