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Treatment of a metabolic liver disease in mice with a transient prime editing approach.

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Title: Treatment of a metabolic liver disease in mice with a transient prime editing approach.
Authors: Rothgangl T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Tálas A; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ioannidi EI; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Weber Y; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Böck D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Matsushita M; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Villiger EA; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Schmidheini L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Moon WJ; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada., Lin PJC; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada., Fan SHY; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada., Marquart KF; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Schwerdel C; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Rimann N; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Faccin E; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Villiger L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Vadovics M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cremonesi A; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Kulcsár PI; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Thöny B; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Kopf M; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Häberle J; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tam YK; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. gerald.schwank@uzh.ch.
Source: Nature biomedical engineering [Nat Biomed Eng] 2025 Oct; Vol. 9 (10), pp. 1705-1718. Date of Electronic Publication: 2025 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rothgangl+T%22">Rothgangl T</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tálas+A%22">Tálas A</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ioannidi+EI%22">Ioannidi EI</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Weber+Y%22">Weber Y</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Böck+D%22">Böck D</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Matsushita+M%22">Matsushita M</searchLink>; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Villiger+EA%22">Villiger EA</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schmidheini+L%22">Schmidheini L</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moon+WJ%22">Moon WJ</searchLink>; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+PJC%22">Lin PJC</searchLink>; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Fan+SHY%22">Fan SHY</searchLink>; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Marquart+KF%22">Marquart KF</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schwerdel+C%22">Schwerdel C</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rimann+N%22">Rimann N</searchLink>; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Faccin+E%22">Faccin E</searchLink>; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Villiger+L%22">Villiger L</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Muramatsu+H%22">Muramatsu H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vadovics+M%22">Vadovics M</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cremonesi+A%22">Cremonesi A</searchLink>; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kulcsár+PI%22">Kulcsár PI</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thöny+B%22">Thöny B</searchLink>; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kopf+M%22">Kopf M</searchLink>; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Häberle+J%22">Häberle J</searchLink>; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tam+YK%22">Tam YK</searchLink>; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Schwank+G%22">Schwank G</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. gerald.schwank@uzh.ch.
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  Data: <searchLink fieldCode="JN" term="%22101696896%22">Nature biomedical engineering</searchLink> [Nat Biomed Eng] 2025 Oct; Vol. 9 (10), pp. 1705-1718. <i>Date of Electronic Publication: </i>2025 May 20.
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