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Compounds with dual glutaminase inhibition and Nrf2 activation activities enhance morphine analgesia and reduce pain sensitization in chemotherapy-induced peripheral neuropathy mouse model.

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Title: Compounds with dual glutaminase inhibition and Nrf2 activation activities enhance morphine analgesia and reduce pain sensitization in chemotherapy-induced peripheral neuropathy mouse model.
Authors: Foster BK; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Kliebe V; Darby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina., Elnaham HF; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Thompson MK; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Sagna SL; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Patton JS; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Brown SC; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana., Chen X; Department of Pharmaceutical and Clinical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, North Carolina., Liu T; Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia., Bowden J; Department of Pharmacology, College of Medicine, University of Arizona, Tuscon, Arizona., Streicher J; Department of Pharmacology, College of Medicine, University of Arizona, Tuscon, Arizona., Lei W; Department of Pharmaceutical and Graduate Life Sciences, College of Health Professions, Nursing & Pharmacy, Manchester University Fort Wayne, Fort Wayne, Indiana. Electronic address: wlei@manchester.edu.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Jun; Vol. 392 (6), pp. 103583. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-0103
DOI:10.1016/j.jpet.2025.103583