Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors.
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| Title: | Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors. |
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| Authors: | Albanese V; Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy., Pedriali G; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy., Fabbri M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Ciancetta A; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Ravagli S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Roccatello C; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Guerrini R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy., Morciano G; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy.; Department of Biosciences, Biotechnology and Environment, University of Bari 'A. Moro', Bari, Italy., Preti D; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Pinton P; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy., Pacifico S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy. |
| Source: | Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2505907. Date of Electronic Publication: 2025 May 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1475-6374 |
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| DOI: | 10.1080/14756366.2025.2505907 |
