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Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors.

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Title: Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors.
Authors: Albanese V; Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy., Pedriali G; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy., Fabbri M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Ciancetta A; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Ravagli S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Roccatello C; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Guerrini R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy., Morciano G; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy.; Department of Biosciences, Biotechnology and Environment, University of Bari 'A. Moro', Bari, Italy., Preti D; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Pinton P; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy., Pacifico S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2505907. Date of Electronic Publication: 2025 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Albanese+V%22">Albanese V</searchLink>; Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pedriali+G%22">Pedriali G</searchLink>; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.<br /><searchLink fieldCode="AU" term="%22Fabbri+M%22">Fabbri M</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Ciancetta+A%22">Ciancetta A</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Ravagli+S%22">Ravagli S</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Roccatello+C%22">Roccatello C</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Guerrini+R%22">Guerrini R</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Morciano+G%22">Morciano G</searchLink>; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy.; Department of Biosciences, Biotechnology and Environment, University of Bari 'A. Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Preti+D%22">Preti D</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pinton+P%22">Pinton P</searchLink>; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.; Technopole of Ferrara, Laboratory for Advanced Therapies (LTTA), Ferrara, Italy.; Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pacifico+S%22">Pacifico S</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2505907. <i>Date of Electronic Publication: </i>2025 May 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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