Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency.
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| Title: | Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency. |
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| Authors: | Zhang X; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Huang L; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; Department of Pharmacy, Shenzhen Clinical Research Center for Neurological Diseases, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China., Li C; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.; Department of Pain Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China., Yang J; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Duan F; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Su Q; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Zhang Y; Department of Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Kou M; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Zhou X; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Guo L; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Chen S; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Niu Y; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Li Z; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Ou S; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China., Zhang M; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Cheng KK; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China., Wu J; Department of Pharmacy, Shenzhen Clinical Research Center for Neurological Diseases, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China., Xu X; State Key Laboratory of Trauma and Chemical Poisoning, Department of Stem Cell and Regenerative Medicine, Daping Hospital, Army Medical University, Chongqing, China., Lian Q; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China. qz.lian@siat.ac.cn.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. qz.lian@siat.ac.cn.; Center for Translational Stem Cell Biology, Hong Kong, and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China. qz.lian@siat.ac.cn. |
| Source: | Cell death discovery [Cell Death Discov] 2025 May 22; Vol. 11 (1), pp. 249. Date of Electronic Publication: 2025 May 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-025-02524-7 |
