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Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies.

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Title: Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies.
Authors: Kallunki P; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark. PEKA@Lundbeck.com., Sotty F; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Willén K; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Lubas M; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., David L; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Ambjørn M; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Bergström AL; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Buur L; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Malik I; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Nyegaard S; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Eriksen TT; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Krogh BO; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Stavenhagen JB; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Andersen KJ; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Pedersen LØ; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Cholak E; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., van den Brink EN; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands., Rademaker R; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands., Vink T; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands., Satijn D; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands., Parren PWHI; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands., Christensen S; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Olsen LR; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Søderberg JN; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Vergo S; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Jensen A; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Egebjerg J; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Wulff-Larsen PG; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Harndahl MN; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Damlund DSM; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Bjerregaard-Andersen K; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark., Fog K; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 May 22; Vol. 11 (1), pp. 132. Date of Electronic Publication: 2025 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies.
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  Data: <searchLink fieldCode="AU" term="%22Kallunki+P%22">Kallunki P</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark. PEKA@Lundbeck.com.<br /><searchLink fieldCode="AU" term="%22Sotty+F%22">Sotty F</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Willén+K%22">Willén K</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Lubas+M%22">Lubas M</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22David+L%22">David L</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Ambjørn+M%22">Ambjørn M</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Bergström+AL%22">Bergström AL</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Buur+L%22">Buur L</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Malik+I%22">Malik I</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Nyegaard+S%22">Nyegaard S</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Eriksen+TT%22">Eriksen TT</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Krogh+BO%22">Krogh BO</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Stavenhagen+JB%22">Stavenhagen JB</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+KJ%22">Andersen KJ</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+LØ%22">Pedersen LØ</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Cholak+E%22">Cholak E</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+EN%22">van den Brink EN</searchLink>; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rademaker+R%22">Rademaker R</searchLink>; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vink+T%22">Vink T</searchLink>; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Satijn+D%22">Satijn D</searchLink>; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Parren+PWHI%22">Parren PWHI</searchLink>; Genmab, Uppsalalaan 15, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Christensen+S%22">Christensen S</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Olsen+LR%22">Olsen LR</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Søderberg+JN%22">Søderberg JN</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Vergo+S%22">Vergo S</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+A%22">Jensen A</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Egebjerg+J%22">Egebjerg J</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Wulff-Larsen+PG%22">Wulff-Larsen PG</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Harndahl+MN%22">Harndahl MN</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Damlund+DSM%22">Damlund DSM</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjerregaard-Andersen+K%22">Bjerregaard-Andersen K</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Fog+K%22">Fog K</searchLink>; H. Lundbeck A/S, Research, Ottiliavej 9, 2500, Valby, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2025 May 22; Vol. 11 (1), pp. 132. <i>Date of Electronic Publication: </i>2025 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101675390 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2373-8057 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738057%22">23738057 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Parkinsons Dis <i>Subsets: </i>PubMed not MEDLINE
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