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Novel pyrazole carboxylate derivatives as lonazolac bioisosteres with selective COX-2 inhibition: design, synthesis and anti-inflammatory activity.

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Title: Novel pyrazole carboxylate derivatives as lonazolac bioisosteres with selective COX-2 inhibition: design, synthesis and anti-inflammatory activity.
Authors: Fadaly WAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Elshewy A; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo, 11562, Egypt.; Department of Natural and Applied Sciences, College of Arts and Sciences, The American University of Iraq-Baghdad (AUIB), Baghdad, Iraq., Abusabaa AHA; Department of Pharmaceutical Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt., Amin DME; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Abdelhady HK; Physiology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Haredy HH; Pharmacology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Mahmoud AM; Biochemistery Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt., Ibrahim NA; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo, 11562, Egypt. Mohamed.nemr@pharma.cu.edu.eg.
Source: Molecular diversity [Mol Divers] 2026 Feb; Vol. 30 (1), pp. 933-958. Date of Electronic Publication: 2025 May 22.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel pyrazole carboxylate derivatives as lonazolac bioisosteres with selective COX-2 inhibition: design, synthesis and anti-inflammatory activity.
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  Data: <searchLink fieldCode="AU" term="%22Fadaly+WAA%22">Fadaly WAA</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.<br /><searchLink fieldCode="AU" term="%22Elshewy+A%22">Elshewy A</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo, 11562, Egypt.; Department of Natural and Applied Sciences, College of Arts and Sciences, The American University of Iraq-Baghdad (AUIB), Baghdad, Iraq.<br /><searchLink fieldCode="AU" term="%22Abusabaa+AHA%22">Abusabaa AHA</searchLink>; Department of Pharmaceutical Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt.<br /><searchLink fieldCode="AU" term="%22Amin+DME%22">Amin DME</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelhady+HK%22">Abdelhady HK</searchLink>; Physiology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.<br /><searchLink fieldCode="AU" term="%22Haredy+HH%22">Haredy HH</searchLink>; Pharmacology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.<br /><searchLink fieldCode="AU" term="%22Mahmoud+AM%22">Mahmoud AM</searchLink>; Biochemistery Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+NA%22">Ibrahim NA</searchLink>; Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.<br /><searchLink fieldCode="AU" term="%22Nemr+MTM%22">Nemr MTM</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo, 11562, Egypt. Mohamed.nemr@pharma.cu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%229516534%22">Molecular diversity</searchLink> [Mol Divers] 2026 Feb; Vol. 30 (1), pp. 933-958. <i>Date of Electronic Publication: </i>2025 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ESCOM+Science+Publishers%22">ESCOM Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9516534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-501X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213811991%22">13811991 </searchLink><i>NLM ISO Abbreviation: </i>Mol Divers <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11030-025-11220-8
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        Text: English
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              Text: 2026 Feb
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