Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial.

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Title: Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial.
Authors: Walther A; Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland. a.walther@psychologie.uzh.ch., Eggenberger L; Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland., Debelak R; Psychological Methods, Evaluation and Statistics, University of Zurich, Zurich, Switzerland., Kirschbaum C; Biological Psychology, TU Dresden, Dresden, Germany., Häberling I; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland., Osuna E; Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland.; Division of Infectious Diseases and Hospital Epidemiology, Children's Research Centre, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Strumberger M; Research Department of Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, University of Basel, Basel, Switzerland., Walitza S; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland., Baumgartner J; Department of Nutritional Sciences, King's College London, London, United Kingdom., Herter-Aeberli I; Laboratroy of Nutrition and Metabolic Epigenetics, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland., Berger G; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Source: Translational psychiatry [Transl Psychiatry] 2025 May 24; Vol. 15 (1), pp. 183. Date of Electronic Publication: 2025 May 24.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-025-03401-8