A plain language summary of POLARIS: a study to look at different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis.

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Title: A plain language summary of POLARIS: a study to look at different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis.
Authors: Menzies AM; aMelanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, Australia., Long GV; aMelanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, Australia., Kohn A; bOregon Health Sciences University, Division of Hematology/Medical Oncology, School of Medicine, Portland, OR, USA., Tawbi H; cUniversity of Texas MD Anderson Cancer Center, Department of Melanoma Medical Oncology Houston, TX, USA., Webe J; dLaura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Flaherty K; eMassachusetts General Hospital, Massachusetts General Cancer Center, Boston, MA, USA., McArthur GA; fPeter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology University of Melbourne, Melbourne, VIC, Australia., Ascierto PA; gAzienda Universitaria Policlinico Federico II, Unit of Melanoma Cancer Immunotherapy and Innovative therapy, Naples, Italy., Pfluger Y; hAlexander Fleming Institute, Buenos Aires, Argentina., Lewis K; iUniversity of Colorado, Health Center, Medical Oncology, Denver, CO, USA., Tsai KK; jUniversity of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA., Hamid O; kThe Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA, USA., Prenen H; lUniversity Hospital Antwerp, Oncology Department, Antwerp, Belgium., Fein L; hAlexander Fleming Institute, Buenos Aires, Argentina., Wang E; mPfizer, New York, NY, USA., Guenzel C; mPfizer, New York, NY, USA., Zhang F; mPfizer, New York, NY, USA., Kleh JF; aMelanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, Australia.; mPfizer, New York, NY, USA., di Pietro A; nPfizer Srl, Milan, Italy., Davies MA; cUniversity of Texas MD Anderson Cancer Center, Department of Melanoma Medical Oncology Houston, TX, USA.
Source: Future oncology (London, England) [Future Oncol] 2025 Jun; Vol. 21 (14), pp. 1703-1711. Date of Electronic Publication: 2025 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101256629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8301 (Electronic) Linking ISSN: 14796694 NLM ISO Abbreviation: Future Oncol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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ISSN:1744-8301
DOI:10.1080/14796694.2025.2495540