Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.

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Title: Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.
Authors: Tarumi T; National Institute of Advanced Industrial Science and Technology, Integrated Research Center for Self-Care Technology, Tsukuba, Ibaraki, Japan.; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan., Won J; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tomoto T; National Institute of Advanced Industrial Science and Technology, Integrated Research Center for Self-Care Technology, Tsukuba, Ibaraki, Japan.; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA., Scheel N; Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, USA., Zhu DC; Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, USA.; Department of Radiology and Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, USA., Ashley J; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Rodrigue KM; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA., Kennedy KM; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA., Park DC; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA., Zhang R; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA. RongZhang@TexasHealth.org.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA. RongZhang@TexasHealth.org.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. RongZhang@TexasHealth.org.
Source: GeroScience [Geroscience] 2026 Feb; Vol. 48 (1), pp. 1079-1096. Date of Electronic Publication: 2025 May 26.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2509-2723
DOI:10.1007/s11357-025-01709-3