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Lenvatinib Plus Pembrolizumab, Pemetrexed, and a Platinum as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 LEAP-006 Study.

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Title: Lenvatinib Plus Pembrolizumab, Pemetrexed, and a Platinum as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 LEAP-006 Study.
Authors: Herbst RS; Yale School of Medicine, Yale Cancer Center, and Smilow Cancer Hospital, New Haven, Connecticut. Electronic address: roy.herbst@yale.edu., Cho BC; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea., Zhou C; Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Burotto M; Centro de Investigación Clínica Bradford Hill, Santiago, Chile., Dols MC; Medical Oncology, Málaga Regional University Hospital, IBIMA, Málaga, Spain., Sendur MAN; Ankara Yıldrım Beyazıt University Faculty of Medicine and Ankara Bilkent City Hospital, Ankara, Turkey., Moiseyenko V; Saint-Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology) named after 'N.P. Napalkov' (GBUZ 'SPb CRPCstmc(o)' named after N.P. Napalkov), St. Petersburg, Russia., Casarini I; Hospital Bernardo Houssay, Mar del Plata, Argentina., Nishio M; Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-Ku, Japan., Hui R; Westmead Hospital and the University of Sydney, Sydney, Australia; Current affiliation: Centre of Cancer Medicine, University of Hong Kong, Hong Kong., Pons-Tostivint E; Nantes University, Centre Hospitalier Universitaire Nantes, Nantes, France., Dudnik J; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka University Medical Center, Beer-Sheva, Israel., Ahmed S; University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom., Okpara CE; Eisai Ltd., Hatfield, United Kingdom., Dutcus C; Eisai Inc., Nutley, New Jersey., Yin L; Merck & Co., Inc., Rahway, New Jersey., Luo Y; Merck & Co., Inc., Rahway, New Jersey., Chirovsky D; Merck & Co., Inc., Rahway, New Jersey., Bhagwati N; Merck & Co., Inc., Rahway, New Jersey., Abreu DR; Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Gran Canaria, Spain.
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2025 Sep; Vol. 20 (9), pp. 1302-1314. Date of Electronic Publication: 2025 May 24.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lenvatinib Plus Pembrolizumab, Pemetrexed, and a Platinum as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 LEAP-006 Study.
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  Data: <searchLink fieldCode="AU" term="%22Herbst+RS%22">Herbst RS</searchLink>; Yale School of Medicine, Yale Cancer Center, and Smilow Cancer Hospital, New Haven, Connecticut. Electronic address: roy.herbst@yale.edu.<br /><searchLink fieldCode="AU" term="%22Cho+BC%22">Cho BC</searchLink>; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Burotto+M%22">Burotto M</searchLink>; Centro de Investigación Clínica Bradford Hill, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Dols+MC%22">Dols MC</searchLink>; Medical Oncology, Málaga Regional University Hospital, IBIMA, Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Sendur+MAN%22">Sendur MAN</searchLink>; Ankara Yıldrım Beyazıt University Faculty of Medicine and Ankara Bilkent City Hospital, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Moiseyenko+V%22">Moiseyenko V</searchLink>; Saint-Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology) named after 'N.P. Napalkov' (GBUZ 'SPb CRPCstmc(o)' named after N.P. Napalkov), St. Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Casarini+I%22">Casarini I</searchLink>; Hospital Bernardo Houssay, Mar del Plata, Argentina.<br /><searchLink fieldCode="AU" term="%22Nishio+M%22">Nishio M</searchLink>; Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-Ku, Japan.<br /><searchLink fieldCode="AU" term="%22Hui+R%22">Hui R</searchLink>; Westmead Hospital and the University of Sydney, Sydney, Australia; Current affiliation: Centre of Cancer Medicine, University of Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Pons-Tostivint+E%22">Pons-Tostivint E</searchLink>; Nantes University, Centre Hospitalier Universitaire Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Dudnik+J%22">Dudnik J</searchLink>; The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka University Medical Center, Beer-Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Ahmed+S%22">Ahmed S</searchLink>; University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Okpara+CE%22">Okpara CE</searchLink>; Eisai Ltd., Hatfield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dutcus+C%22">Dutcus C</searchLink>; Eisai Inc., Nutley, New Jersey.<br /><searchLink fieldCode="AU" term="%22Yin+L%22">Yin L</searchLink>; Merck & Co., Inc., Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Merck & Co., Inc., Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Chirovsky+D%22">Chirovsky D</searchLink>; Merck & Co., Inc., Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Bhagwati+N%22">Bhagwati N</searchLink>; Merck & Co., Inc., Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Abreu+DR%22">Abreu DR</searchLink>; Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Gran Canaria, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101274235%22">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</searchLink> [J Thorac Oncol] 2025 Sep; Vol. 20 (9), pp. 1302-1314. <i>Date of Electronic Publication: </i>2025 May 24.
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  Data: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274235 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1556-1380 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215560864%22">15560864 </searchLink><i>NLM ISO Abbreviation: </i>J Thorac Oncol <i>Subsets: </i>MEDLINE
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