Feasibility of multiomics tumor profiling for guiding treatment of melanoma.

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Bibliographic Details
Title: Feasibility of multiomics tumor profiling for guiding treatment of melanoma.
Authors: Miglino N; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Toussaint NC; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Swiss Data Science Center SDSC, Zurich, Switzerland., Ring A; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Bonilla X; Department of Computer Science, Institute of Machine Learning, ETH Zurich, Zurich, Switzerland., Tusup M; Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Gosztonyi B; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Mehra T; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Gut G; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Jacob F; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Chevrier S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Lehmann KV; Department of Computer Science, Institute of Machine Learning, ETH Zurich, Zurich, Switzerland.; Department of Biology, RWTH Aachen, Aachen, Germany., Casanova R; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Jacobs A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Sivapatham S; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Boos L; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Rahimzadeh P; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Schuerch M; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Sobottka B; Department of Pathology and Molecular Pathology, University of Zurich and University Hospital, Zurich, Switzerland., Chicherova N; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Yu S; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Swiss Data Science Center SDSC, Zurich, Switzerland., Wegmann R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Mena J; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Milani ES; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Goetze S; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), ETH Zurich, Zurich, Switzerland., Esposito C; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Sarabia Del Castillo J; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Frei AL; Department of Pathology and Molecular Pathology, University of Zurich and University Hospital, Zurich, Switzerland., Nowak M; Department of Pathology and Molecular Pathology, University of Zurich and University Hospital, Zurich, Switzerland., Irmisch A; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Zurich, Switzerland., Kuipers J; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Baciu-Drăgan MA; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Ferreira PF; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Singer F; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Bertolini A; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Prummer M; NEXUS Personalized Health Technologies, ETH Zurich, Zurich, Switzerland.; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Lischetti U; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Bacac M; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Zurich, Switzerland., Maass G; Roche Diagnostics GmbH, MWG, Penzberg, Germany., Moch H; Department of Pathology and Molecular Pathology, University of Zurich and University Hospital, Zurich, Switzerland., Weller M; Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland., Theocharides APA; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Manz MG; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland., Beerenwinkel N; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Beisel C; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Pelkmans L; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Snijder B; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Wollscheid B; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Heinzelmann V; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Bodenmiller B; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Levesque MP; Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Koelzer VH; Department of Pathology and Molecular Pathology, University of Zurich and University Hospital, Zurich, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Rätsch G; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Computer Science, Institute of Machine Learning, ETH Zurich, Zurich, Switzerland.; Biomedical Informatics, University Hospital Zurich, Zurich, Switzerland.; AI Center at ETH Zurich, ETH Zurich, Zurich, Switzerland.; Department of Biology, ETH Zurich, Zurich, Switzerland., Dummer R; Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Wicki A; Department of Medical Oncology and Hematology, University of Zurich and University Hospital, Zurich, Switzerland. andreas.wicki@usz.ch.
Corporate Authors: Tumor Profiler Consortium
Source: Nature medicine [Nat Med] 2025 Jul; Vol. 31 (7), pp. 2430-2441. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-025-03715-6