TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.
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| Title: | TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice. |
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| Authors: | Bergh S; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Casadei N; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany., Gabery S; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Simonsson O; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Duarte JMN; Diabetes and Brain Function Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., Kirik D; Brain Repair and Imaging in Neural Systems (BRAINS), Department of Experimental Medical Science, Lund University, Lund, Sweden., Nguyen HP; Department of Human Genetics, Medical Faculty, Ruhr University Bochum, Bochum, Germany., Petersén Å; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden. asa.petersen@med.lu.se.; Department of Psychiatry, Skåne University Hospital, Lund, Sweden. asa.petersen@med.lu.se. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2025 May 27; Vol. 13 (1), pp. 119. Date of Electronic Publication: 2025 May 27. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2051-5960 |
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| DOI: | 10.1186/s40478-025-02018-8 |
