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TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.

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Title: TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.
Authors: Bergh S; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Casadei N; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany., Gabery S; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Simonsson O; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden., Duarte JMN; Diabetes and Brain Function Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., Kirik D; Brain Repair and Imaging in Neural Systems (BRAINS), Department of Experimental Medical Science, Lund University, Lund, Sweden., Nguyen HP; Department of Human Genetics, Medical Faculty, Ruhr University Bochum, Bochum, Germany., Petersén Å; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden. asa.petersen@med.lu.se.; Department of Psychiatry, Skåne University Hospital, Lund, Sweden. asa.petersen@med.lu.se.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 May 27; Vol. 13 (1), pp. 119. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.
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  Data: <searchLink fieldCode="AU" term="%22Bergh+S%22">Bergh S</searchLink>; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden.<br /><searchLink fieldCode="AU" term="%22Casadei+N%22">Casadei N</searchLink>; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; NGS Competence Center Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gabery+S%22">Gabery S</searchLink>; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden.<br /><searchLink fieldCode="AU" term="%22Simonsson+O%22">Simonsson O</searchLink>; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden.<br /><searchLink fieldCode="AU" term="%22Duarte+JMN%22">Duarte JMN</searchLink>; Diabetes and Brain Function Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Kirik+D%22">Kirik D</searchLink>; Brain Repair and Imaging in Neural Systems (BRAINS), Department of Experimental Medical Science, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Nguyen+HP%22">Nguyen HP</searchLink>; Department of Human Genetics, Medical Faculty, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Petersén+Å%22">Petersén Å</searchLink>; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Lund University, BMC D11, Lund, 221 84, Sweden. asa.petersen@med.lu.se.; Department of Psychiatry, Skåne University Hospital, Lund, Sweden. asa.petersen@med.lu.se.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2025 May 27; Vol. 13 (1), pp. 119. <i>Date of Electronic Publication: </i>2025 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s40478-025-02018-8
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        Text: English
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              Text: 2025 May 27
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