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BRAF oncogenic mutants evade autoinhibition through a common mechanism.

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Title: BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Authors: Lavoie H; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Jin T; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Lajoie D; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Decossas M; Université de Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, Pessac, France., Gendron P; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Wang B; Cryo-EM Core Facility, NYU Langone Health, New York, NY, USA., Filandr F; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Sahmi M; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Hwa Jo C; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Weber S; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Arseneault G; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Tripathy S; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Beaulieu P; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Schuetz DA; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada., Schriemer DC; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Marinier A; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.; Département de Chimie, Université de Montréal, Montréal, QC, Canada., Rice WJ; Cryo-EM Core Facility, NYU Langone Health, New York, NY, USA.; Department of Cell Biology, NYU Langone Health, New York, NY, USA., Maisonneuve P; Université de Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, Pessac, France., Therrien M; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, QC, Canada.
Source: Science (New York, N.Y.) [Science] 2025 May 29; Vol. 388 (6750), pp. eadp2742. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lavoie+H%22">Lavoie H</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Jin+T%22">Jin T</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Lajoie+D%22">Lajoie D</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Decossas+M%22">Decossas M</searchLink>; Université de Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Gendron+P%22">Gendron P</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Cryo-EM Core Facility, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Filandr+F%22">Filandr F</searchLink>; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Sahmi+M%22">Sahmi M</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Hwa+Jo+C%22">Hwa Jo C</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Weber+S%22">Weber S</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Arseneault+G%22">Arseneault G</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Tripathy+S%22">Tripathy S</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Beaulieu+P%22">Beaulieu P</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Schuetz+DA%22">Schuetz DA</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Schriemer+DC%22">Schriemer DC</searchLink>; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Marinier+A%22">Marinier A</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.; Département de Chimie, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rice+WJ%22">Rice WJ</searchLink>; Cryo-EM Core Facility, NYU Langone Health, New York, NY, USA.; Department of Cell Biology, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Maisonneuve+P%22">Maisonneuve P</searchLink>; Université de Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Therrien+M%22">Therrien M</searchLink>; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, QC, Canada.
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