D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.

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Title: D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.
Authors: Durço AO; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Souza DS; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil. Electronic address: santos.dss@outlook.com., Lima Conceição MR; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Beserra SDS; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Teixeira da Fonseca JL; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Loch L; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Silva MA; Department of Structural and Functional Biology, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Pereira de Oliveira A; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, 64049-550, Brazil., Araujo AAS; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Pharmacy, Federal University of Sergipe, Aracaju, 49107-230, Brazil., Lins de Vasconcelos CM; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil., Cruz JS; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31.270-901, Brazil., Roman-Campos D; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil. Electronic address: drcampos@unifesp.br., Viana Dos Santos MR; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil.
Source: Chemico-biological interactions [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111580. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7786
DOI:10.1016/j.cbi.2025.111580