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D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.

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Title: D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.
Authors: Durço AO; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Souza DS; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil. Electronic address: santos.dss@outlook.com., Lima Conceição MR; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Beserra SDS; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Teixeira da Fonseca JL; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Loch L; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Silva MA; Department of Structural and Functional Biology, Federal University of São Paulo, São Paulo, 04023-062, Brazil., Pereira de Oliveira A; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, 64049-550, Brazil., Araujo AAS; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Pharmacy, Federal University of Sergipe, Aracaju, 49107-230, Brazil., Lins de Vasconcelos CM; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil., Cruz JS; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31.270-901, Brazil., Roman-Campos D; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil. Electronic address: drcampos@unifesp.br., Viana Dos Santos MR; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil.
Source: Chemico-biological interactions [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111580. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
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  Data: D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.
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  Data: <searchLink fieldCode="AU" term="%22Durço+AO%22">Durço AO</searchLink>; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+DS%22">Souza DS</searchLink>; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil. Electronic address: santos.dss@outlook.com.<br /><searchLink fieldCode="AU" term="%22Lima+Conceição+MR%22">Lima Conceição MR</searchLink>; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Beserra+SDS%22">Beserra SDS</searchLink>; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Teixeira+da+Fonseca+JL%22">Teixeira da Fonseca JL</searchLink>; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Loch+L%22">Loch L</searchLink>; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+MA%22">Silva MA</searchLink>; Department of Structural and Functional Biology, Federal University of São Paulo, São Paulo, 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+de+Oliveira+A%22">Pereira de Oliveira A</searchLink>; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Araujo+AAS%22">Araujo AAS</searchLink>; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Pharmacy, Federal University of Sergipe, Aracaju, 49107-230, Brazil.<br /><searchLink fieldCode="AU" term="%22Lins+de+Vasconcelos+CM%22">Lins de Vasconcelos CM</searchLink>; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil.<br /><searchLink fieldCode="AU" term="%22Cruz+JS%22">Cruz JS</searchLink>; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, 31.270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Roman-Campos+D%22">Roman-Campos D</searchLink>; Department of Biophysics, Federal University of São Paulo, São Paulo, 04023-062, Brazil. Electronic address: drcampos@unifesp.br.<br /><searchLink fieldCode="AU" term="%22Viana+Dos+Santos+MR%22">Viana Dos Santos MR</searchLink>; Health Science Graduate Program, Federal University of Sergipe, Aracaju, 49060-108, Brazil; Department of Physiology, Federal University of Sergipe, Aracaju, 49107-230, Brazil.
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  Data: <searchLink fieldCode="JN" term="%220227276%22">Chemico-biological interactions</searchLink> [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111580. <i>Date of Electronic Publication: </i>2025 May 27.
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