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Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells.

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Title: Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells.
Authors: Ho TT; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Huang H; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Li YL; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Huang ZX; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Nguyen VP; Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy, Hue University, Thua Thien Hue, 49000, Vietnam., Al-Samhari GA; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Aschner M; Department of Molecular Pharmacology at Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Li ZC; Institute of Brain and Mental Diseases, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China. lizhaocong1064@163.com., Jiang YM; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China. ymjianggxmu@163.com.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China. ymjianggxmu@163.com.
Source: Biological trace element research [Biol Trace Elem Res] 2026 Jan; Vol. 204 (1), pp. 288-299. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-0720
DOI:10.1007/s12011-025-04681-3