Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells.

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Title: Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells.
Authors: Ho TT; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Huang H; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Li YL; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Huang ZX; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China., Nguyen VP; Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy, Hue University, Thua Thien Hue, 49000, Vietnam., Al-Samhari GA; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Aschner M; Department of Molecular Pharmacology at Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Li ZC; Institute of Brain and Mental Diseases, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China. lizhaocong1064@163.com., Jiang YM; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China. ymjianggxmu@163.com.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China. ymjianggxmu@163.com.
Source: Biological trace element research [Biol Trace Elem Res] 2026 Jan; Vol. 204 (1), pp. 288-299. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Wnt/β-catenin Pathway Activation Reverses Tau Hyperphosphorylation and β-Amyloid Accumulation Induced by Combined Manganese and Iron Exposure in PC12 Cells.
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  Data: <searchLink fieldCode="AU" term="%22Ho+TT%22">Ho TT</searchLink>; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China.<br /><searchLink fieldCode="AU" term="%22Li+YL%22">Li YL</searchLink>; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China.<br /><searchLink fieldCode="AU" term="%22Huang+ZX%22">Huang ZX</searchLink>; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China.<br /><searchLink fieldCode="AU" term="%22Nguyen+VP%22">Nguyen VP</searchLink>; Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy, Hue University, Thua Thien Hue, 49000, Vietnam.<br /><searchLink fieldCode="AU" term="%22Al-Samhari+GA%22">Al-Samhari GA</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Aschner+M%22">Aschner M</searchLink>; Department of Molecular Pharmacology at Albert Einstein College of Medicine, Bronx, NY, 10461, USA.<br /><searchLink fieldCode="AU" term="%22Li+ZC%22">Li ZC</searchLink>; Institute of Brain and Mental Diseases, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China. lizhaocong1064@163.com.<br /><searchLink fieldCode="AU" term="%22Jiang+YM%22">Jiang YM</searchLink>; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Nanning, 530021, Guangxi, China. ymjianggxmu@163.com.; Key Laboratory of Prevention and Control of Highly Prevalent Diseases in Guangxi Colleges and Universities, Medical University of Guangxi, Nanning, 530021, China. ymjianggxmu@163.com.
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  Data: <searchLink fieldCode="JN" term="%227911509%22">Biological trace element research</searchLink> [Biol Trace Elem Res] 2026 Jan; Vol. 204 (1), pp. 288-299. <i>Date of Electronic Publication: </i>2025 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7911509 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-0720 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201634984%22">01634984 </searchLink><i>NLM ISO Abbreviation: </i>Biol Trace Elem Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12011-025-04681-3
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        Text: English
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              Text: 2026 Jan
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              Y: 2026
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