Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer.

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Title: Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer.
Authors: Cook SR; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., Hugen S; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Hayward JJ; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., Famula TR; Department of Animal Science, University of California, Davis, CA 95616., Belanger JM; Department of Animal Science, University of California, Davis, CA 95616., McNiel E; Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536., Fieten H; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Oberbauer AM; Department of Animal Science, University of California, Davis, CA 95616., Leegwater PAJ; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892., Mandigers PJJ; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Evans JM; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jun 03; Vol. 122 (22), pp. e2416723122. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2416723122