Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer.

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Title: Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer.
Authors: Cook SR; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., Hugen S; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Hayward JJ; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., Famula TR; Department of Animal Science, University of California, Davis, CA 95616., Belanger JM; Department of Animal Science, University of California, Davis, CA 95616., McNiel E; Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536., Fieten H; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Oberbauer AM; Department of Animal Science, University of California, Davis, CA 95616., Leegwater PAJ; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892., Mandigers PJJ; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands., Evans JM; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jun 03; Vol. 122 (22), pp. e2416723122. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer.
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  Data: <searchLink fieldCode="AU" term="%22Cook+SR%22">Cook SR</searchLink>; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.<br /><searchLink fieldCode="AU" term="%22Hugen+S%22">Hugen S</searchLink>; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hayward+JJ%22">Hayward JJ</searchLink>; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.<br /><searchLink fieldCode="AU" term="%22Famula+TR%22">Famula TR</searchLink>; Department of Animal Science, University of California, Davis, CA 95616.<br /><searchLink fieldCode="AU" term="%22Belanger+JM%22">Belanger JM</searchLink>; Department of Animal Science, University of California, Davis, CA 95616.<br /><searchLink fieldCode="AU" term="%22McNiel+E%22">McNiel E</searchLink>; Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536.<br /><searchLink fieldCode="AU" term="%22Fieten+H%22">Fieten H</searchLink>; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Oberbauer+AM%22">Oberbauer AM</searchLink>; Department of Animal Science, University of California, Davis, CA 95616.<br /><searchLink fieldCode="AU" term="%22Leegwater+PAJ%22">Leegwater PAJ</searchLink>; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ostrander+EA%22">Ostrander EA</searchLink>; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.<br /><searchLink fieldCode="AU" term="%22Mandigers+PJJ%22">Mandigers PJJ</searchLink>; Expertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Evans+JM%22">Evans JM</searchLink>; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
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