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Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients-a post-hoc analysis of the HYPRESS trial.

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Title: Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients-a post-hoc analysis of the HYPRESS trial.
Authors: Neumann C; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. caroline.neumann@med.uni-jena.de., Leitner M; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany., Bloos F; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany., Lange D; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany., Bogatsch H; Institute for Medical Informatics, Statistics and Epidemiology (IMISE) and Clinical Trial Centre, Leipzig University, Härtelstraße 16-18, 04107, Leipzig, Germany., Annane D; IHU PROMETHEUS, Comprehensive Sepsis Centre, Hôpital Raymond Poincaré, Assistance Publique, Hôpitaux de Paris (APHP), 104 Boulevard Raymond Poincaré, 92380, Garches, France., Fleuriet J; IHU PROMETHEUS, Comprehensive Sepsis Centre, Hôpital Raymond Poincaré, Assistance Publique, Hôpitaux de Paris (APHP), 104 Boulevard Raymond Poincaré, 92380, Garches, France., Briegel J; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany., Bauer M; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
Corporate Authors: SepNet Critical Care Trials Group, iRECORDS collaborators
Source: Infection [Infection] 2025 Dec; Vol. 53 (6), pp. 2383-2395. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients-a post-hoc analysis of the HYPRESS trial.
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  Data: <searchLink fieldCode="AU" term="%22Neumann+C%22">Neumann C</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. caroline.neumann@med.uni-jena.de.<br /><searchLink fieldCode="AU" term="%22Leitner+M%22">Leitner M</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Bloos+F%22">Bloos F</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Lange+D%22">Lange D</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bogatsch+H%22">Bogatsch H</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE) and Clinical Trial Centre, Leipzig University, Härtelstraße 16-18, 04107, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Annane+D%22">Annane D</searchLink>; IHU PROMETHEUS, Comprehensive Sepsis Centre, Hôpital Raymond Poincaré, Assistance Publique, Hôpitaux de Paris (APHP), 104 Boulevard Raymond Poincaré, 92380, Garches, France.<br /><searchLink fieldCode="AU" term="%22Fleuriet+J%22">Fleuriet J</searchLink>; IHU PROMETHEUS, Comprehensive Sepsis Centre, Hôpital Raymond Poincaré, Assistance Publique, Hôpitaux de Paris (APHP), 104 Boulevard Raymond Poincaré, 92380, Garches, France.<br /><searchLink fieldCode="AU" term="%22Briegel+J%22">Briegel J</searchLink>; Department of Anaesthesiology, LMU University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
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  Data: <searchLink fieldCode="CA" term="%22SepNet+Critical+Care+Trials+Group%22">SepNet Critical Care Trials Group</searchLink><br /><searchLink fieldCode="CA" term="%22iRECORDS+collaborators%22">iRECORDS collaborators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220365307%22">Infection</searchLink> [Infection] 2025 Dec; Vol. 53 (6), pp. 2383-2395. <i>Date of Electronic Publication: </i>2025 May 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Heidelberg%22">Springer Heidelberg </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0365307 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1439-0973 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203008126%22">03008126 </searchLink><i>NLM ISO Abbreviation: </i>Infection <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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