Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects.

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Title: Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects.
Authors: Oh J; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore., Muralidharan S; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore., Zhao Q; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Scholz J; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany., Zelnik ID; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Blumenreich S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Joseph T; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Dingjan T; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Narayanaswamy P; Sciex, R&D, Singapore., Choi H; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hayen H; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany., Torta F; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore. Electronic address: bchfdtt@nus.edu.sg., Futerman AH; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Source: Journal of lipid research [J Lipid Res] 2025 Jul; Vol. 66 (7), pp. 100832. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1539-7262
DOI:10.1016/j.jlr.2025.100832