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Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects.

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Title: Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects.
Authors: Oh J; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore., Muralidharan S; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore., Zhao Q; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Scholz J; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany., Zelnik ID; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Blumenreich S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Joseph T; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Dingjan T; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Narayanaswamy P; Sciex, R&D, Singapore., Choi H; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hayen H; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany., Torta F; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore. Electronic address: bchfdtt@nus.edu.sg., Futerman AH; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Source: Journal of lipid research [J Lipid Res] 2025 Jul; Vol. 66 (7), pp. 100832. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects.
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  Data: <searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Muralidharan+S%22">Muralidharan S</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Scholz+J%22">Scholz J</searchLink>; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Zelnik+ID%22">Zelnik ID</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Blumenreich+S%22">Blumenreich S</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Joseph+T%22">Joseph T</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Dingjan+T%22">Dingjan T</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Narayanaswamy+P%22">Narayanaswamy P</searchLink>; Sciex, R&D, Singapore.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Cardiovascular-Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hayen+H%22">Hayen H</searchLink>; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Torta+F%22">Torta F</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore. Electronic address: bchfdtt@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Futerman+AH%22">Futerman AH</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
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  Data: <searchLink fieldCode="JN" term="%220376606%22">Journal of lipid research</searchLink> [J Lipid Res] 2025 Jul; Vol. 66 (7), pp. 100832. <i>Date of Electronic Publication: </i>2025 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0376606 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1539-7262 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222275%22">00222275 </searchLink><i>NLM ISO Abbreviation: </i>J Lipid Res <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul
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